Alkeev N., Averin S., von Gratowski S. New Method for Monitoring the Process of Freeze Drying of Biological Materials. AAPS Pharm Sci Tech An Official Journal of the American Association of Pharmaceutical Scientists , 2015 , 16 (6). С. 1474-1479. ISSN 1530-9932
Полный текст не доступен из этого репозитория.Аннотация
A capacitive sensor was proposed and tested for the monitoring and control of a freeze drying process of a vaccine against the Newcastle disease of birds. The residual moisture of the vaccine was measured by the thermogravimetric method. The vaccine activity was determined by titration in chicken embryos. It was shown that, at the stages of freezing and primary drying, a capacitive sensor measured the fraction of unfrozen liquid phase in a material and allowed one to control the sublimation stage of drying in an optimal way. This prevented the foaming of the material and shortened the total drying time approximately twice. The control range at the sublimation stage of drying expanded up to −70°C. It was found at the final stage of drying that the signal of a capacitive sensor passed through a maximum value. We supposed that this maximum corresponds to the minimum of intramolecular mobility of biological macromolecules and hence to the optimal residual moisture of the material, which ensures long-term preservation of its activity. We also suppose that using the capacitive sensor at the final stage of drying allows one to more precisely detect the time when the residual moisture of dried material reaches theoptimal value.
| Тип объекта: | Статья |
|---|---|
| Авторы на русском. ОБЯЗАТЕЛЬНО ДЛЯ АНГЛОЯЗЫЧНЫХ ПУБЛИКАЦИЙ!: | Алкеев Н., Аверин С., фон Гратовски С. |
| Подразделения (можно выбрать несколько, удерживая Ctrl): | 176 лаб. твердотельной электроники миллиметрового диапазона 257 лаб. быстропротекающих оптических явлений в твердотельных структурах |
| URI: | http://cplire.ru:8080/id/eprint/483 |
 |
Изменить объект |
