Yaroslavov A.A., Sitnikova T. A., Rakhnyanskaya A.A., Yaroslavova E.G., Sybachin A.V., Melik-Nubarov N.S., Khomutov G.B. Variable and low-toxic polyampholytes: complexation with biological membranes. Colloid and Polymer Science , 2017 , 295 (8). С. 1405-1417. ISSN 0303-402X
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In this paper, we describe three series of polyampholytes synthesized via quaternization of poly(4-vinylpyridin) by ω-bromocarboxylic acids and alkyl bromides: (1) with cationic and anionic groups in each unit (polybetaines), (2) with betaine and cationic groups, and (3) with betaine and pendant alkyl groups. The polymers were complexed with anionic mixed lipid membranes, liposomes, and Langmuir monolayers. By varying a length of –(CH2)n– spacer in the betaine group, different behaviors of polybetaines in a suspension of anionic liposomes can be realized: from no interaction to complexation followed by significant structural reorganization in the liposomal membrane. Cytotoxicities of polyampholytes are one to two orders of magnitude less than the cytotoxicity of a pure polycationic polymer with the same degree of polymerization. These results are of importance in designing polyelectrolytes with a higher affinity to the biolodical (cell) membrane and minimum cytotoxicity and demonstrate the potential of polyampholytes in developing biocompatible polymeric structures.
| Тип объекта: | Статья |
|---|---|
| Авторы на русском. ОБЯЗАТЕЛЬНО ДЛЯ АНГЛОЯЗЫЧНЫХ ПУБЛИКАЦИЙ!: | Ярославов А.А., Ситникова Т.А., Рахнянская А.А., Ярославова Е.Г., Сыбачин А.В., Мелик-Нубаров Н.С., Хомутов Г.Б. |
| Подразделения (можно выбрать несколько, удерживая Ctrl): | 164 лаб. устройств молекулярной и биологической электроники |
| URI: | http://cplire.ru:8080/id/eprint/3892 |
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