Khomutov G.B., Kim V.P., Koksharov Yu. A., Potapenkov K.V., Yaroslavov A.A., Yaroslavova E.G., Sybachin A.V., Faikin V.V., Vdovin V.A., Taranov I.V., Tiukavin V. I., Cherepenin V.A., Gulyaev Yu.V. Nanocomposite Membraneous Vesicles Based on The Interfacial Complexes of Polyelectrolytes, Amphiphiles and Nanoparticles. In: 11-th International Symposium on Polyelectrolytes, June 27 – 30, 2016, Lomonosov Moscow State University, Moscow, Russia , р. 156.
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Development and study of novel biomimetic and biocompatible complex organic-inorganic functional nanomaterials are currently important from fundamental and applied viewpoints. We present results of design, preparation and characterization of new nanocomposite biocompatible magnetic membraneous vesicles based on the interfacial complexes of polyelectrolytes, biogenic lipids, functional amphiphiles and inorganic nanoparticles (magnetic iron oxide nanoparticles and plasmonic Au nanoparticles) which can be prospective for development of novel efficient means for capsulation, targeted transport, controlled spatial localization, remote activation and stimuli-addressed delivery of various compounds in aqueous media for biomedical controlled drug delivery and other applications. The features of interactions of colloid magnetite nanoparticles, gold nanoparticles and polyelectrolytes with liposomes formed by phosphatidylcholine and stearoylspermine have been studied. Nanocomposite vesicles were prepared by sequential adsorption of colloid nanoparticles and polyelectrolytes onto the cationic hybrid liposomes preliminarily formed using conventional ultrasound method. The obtained vesicles were characterized by transmission electron microscopy (TEM), atomic force microscopy (AFM), electron magnetic resonance technique, laser light scattering, electrophoresis, conductometry, etc. The study of the effect of ultrashort high strength electromagnetic pulses on those capsules have been carried out and the non- thermal decapsulation effect and efficient delivery of capsulated model compound was observed. TEM and AFM data showed that the structure of vesicles was destroyed substantially due to the electromagnetic treatment. It was experimentally demonstrated and theoretically proved that the presence of conducting nanoparticles in the vesicle membrane can decrease substantially the voltage of applied electric pulses resulting in the membrane structural changes and vesicle "opening" [1]. It was found that additional polyelectrolyte complex layers formed on the surface of nanocomposite liposomes can change substantially the physical-chemical characteristics of such liposomes and their stability and resistivity against external factors as electromagnetic fields.
| Тип объекта: | Доклад на конференции или семинаре (Постер) |
|---|---|
| Авторы на русском. ОБЯЗАТЕЛЬНО ДЛЯ АНГЛОЯЗЫЧНЫХ ПУБЛИКАЦИЙ!: | Хомутов Г.Б., Ким В.П., Кокшаров Ю.А., Потапенков К.В., Ярославов А.А., Ярославова Е.Г., Сыбачин А.В., Файкин В.В., Вдовин В.А., Таранов И.В., Тюкавин В.И., Черепенин В.А., Гуляев Ю.В. |
| Подразделения (можно выбрать несколько, удерживая Ctrl): | 164 лаб. устройств молекулярной и биологической электроники 201 лаб. математических методов радиофизики |
| URI: | http://cplire.ru:8080/id/eprint/3759 |
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