Ivashkov O.V., Sybachin A.V., Efimova A.A., Pergushov D.V., Orlov V.N., Schmalz H., Yaroslavov A.A. The Influence of the Chain Length of Polycations on their Complexation with Anionic Liposomes. CHEMPHYSCHEM: A EUROPEAN JOURNAL OF CHEMICAL PHYSICS AND PHYSICAL CHEMISTRY , 2015 , 16 (13). С. 2849-2853.
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Аннотация
A series of strong polycations is synthesized through the anionic polymerization of 2-vinylpyridine, followed by subsequent quaternization of the resulting polymer. Polycations based on quaternized 2-vinylpyridine (PVPQs) with degrees of polymerization (DP) from 20 to 440 are adsorbed on the surface of small anionic liposomes. Liposome/PVPQ complexes are characterized by using a number of physicochemical methods. All PVPQs are totally adsorbed onto the liposome surface up to a certain concentration at which saturation is reached (which is specific for each PVPQ). The integrity of the adsorbed liposomes remains intact. Short PVPQs interact with anionic lipids localized on the outer membrane leaflet, whereas long PVPQs extract anionic lipids from the inner to outer leaflet. Complexes tend to aggregate, and the largest aggregates are formed when the initial charge of the liposomes is fully neutralized by the charge of the PVPQ. PVPQs with intermediate DPs demonstrate behavioral features of both short and long PVPQs. These results are important for the interpretation of the biological effects of cationic polymers and the selection of cationic polymers for biomedical applications.
| Тип объекта: | Статья |
|---|---|
| Авторы на русском. ОБЯЗАТЕЛЬНО ДЛЯ АНГЛОЯЗЫЧНЫХ ПУБЛИКАЦИЙ!: | Ивашков О.В. Сыбачин А.В. Ефимова А.А. Пегушов Д.В. Орлов В.Н. Ярославов А.А. |
| Подразделения (можно выбрать несколько, удерживая Ctrl): | 164 лаб. устройств молекулярной и биологической электроники |
| URI: | http://cplire.ru:8080/id/eprint/781 |
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- The Influence of the Chain Length of Polycations on their Complexation with Anionic Liposomes. (deposited 13 Июн 2016 18:52) [В настоящее время Отображен]
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