Pavlyukova E.R., Gulyaev Yu.V., Cherepenin V.A., Taranov I.V. Remote decapsulation of liposomal capsules by ultrashort electric pulses. In: XXXIII International Conference on Equations of State for Matter, March 1–6, 2018, Elbrus, Kabardino-Balkaria, Russia , р. 308.
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Further progress in biotechnology and biomedicine depends on the creation of novel functional biocompatible and bioactive materi-als, efficient systems for capsulation and targeted delivery of var-ious functional active compounds. The success in the directions is determined by solution of correlated physical, chemical, biological and nanotechnological tasks and becomes now challenging interdis-ciplinary problem. The main questions that have to be solved are the following: (i) How the drug could be capsulated by the carrier and then delivered to definite local area? (ii) How the drug could be delivered and removed from the carrier by a controlled way? (iii) How to decrease potential toxicity of the used materials to minimize their possible negative effects on the organism? The authors make efforts to develop new prospective system for capsulation and controlled targeted delivery of various compounds in aqueous media based on the colloid nanocomposite vesicles and capsules representing hybrid constructions formed by polymers (in-cluding biopolymers and inter-polyelectrolyte complexes), lipids and amphiphiles, inorganic nanoparticles and other functional compo-nents. The electric pulses effects on the nanocomposite capsules and remote non-thermal activation of capsules have been studied. Obtained results confirm the possibility to form hybrid nanocom-posite magnetic vesicles and capsules composed of lipids, polymers and nanoparticles whose spatial localization, structure and perme-ability could be changed remotely by a controllable way through corresponding electromagnetic pulses.
| Тип объекта: | Доклад на конференции или семинаре (Доклад) |
|---|---|
| Авторы на русском. ОБЯЗАТЕЛЬНО ДЛЯ АНГЛОЯЗЫЧНЫХ ПУБЛИКАЦИЙ!: | Павлюкова Е.Р., Гуляев Ю.В., Черепенин В.А., Таранов И.В. |
| Подразделения (можно выбрать несколько, удерживая Ctrl): | 164 лаб. устройств молекулярной и биологической электроники |
| URI: | http://cplire.ru:8080/id/eprint/6519 |
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