Vdovin V.A., Gulyaev Yu.V., Cherepenin V.A., Taranov I.V., Yaroslavov A.A., Kim V.P., Khomutov G.B. Ultrashort Electric Pulses Decapsulation of Nanocomposite Liposomal Capsules Containing Gold Nanorods. In: 6th Euro-Asian Pulsed Power Conference with the 21st International Conference on High-Power Particle Beams and the 15th International Conference on Megagauss Magnetic Field Generation, from 18 to 22 September 2016, Estoril Congress Center, Lisbon, Portugal , С. 147-148.
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The possibility of carrying out the controlled address delivery of drugs occupies an important place among modern investigations in the area of nanotechnologies. The problem of the effective and, at the same time, safe (for surrounding biological structures) liberation of the encapsulated substance from the container is the most complex and urgent. Works on changes in the permeability of container shells with the use of laser radiation, microwave fields, alternating magnetic field, and changes in the chemical composition of the environment are devoted to solution of this problem [1–4]. One of the most promising approaches to creation of the drug containers sensitive to external electromagnetic action is the use of inorganic particles in its nanocomposite structure. As a rule, inorganic nanoparticles having different nature and composition (metal, magnetic, and semiconducting) possess a set of physical and chemical properties, which differ substantially from the properties of corresponding macrovolumetric materials. This quality makes such nanoparticles unique and interesting objects of basic research and important functional components of promising devices and technologies. For example, the single-electron tunnel transistor operating at the room temperature was for first developed with the use of metal nanoclusters [5– 7]. Metal and magnetic nanoparticles are widely used in nanobiomedical technologies for diagnostics and therapy [8]. Inclusion of magnetic nanoparticles into the structure of polyelectrolyte capsules has made these capsules sensitive to the external microwave action, which can controllably change the structure and permeability of the shells of these capsules [3–5]. Metal and semiconductor nanoparticles with a substantially elongated shape (nanorods) and their organized ensembles possess anisotropic optical properties. Using DNA molecules as an adsorbing matrix, quasilinear structures of semiconductor CdSe nanorods were created. Fluorescence of these structures was polarized [5, 9]. In this study, liposomal nanocomposite capsules containing gold nanorods sensitive to the external pulse electric action were synthesized using the technique from [10]. The duration of the applied electric pulses was about 10 ns. The decapsulation effect of nanocomposite liposomal capsules containing anisotropic gold nanoparticles (nanorods), which is caused by the action of ultrashort (on the order of 10 ns) electric pulses with high intensities (up to 100 kV/m) on these capsules, is discovered. The mechanism of destruction of liposomal shells of the capsules near poles of conducting gold nanorods under the pulse electric action is described. An expression for the critical intensity of the pulse electric field, which determines the threshold of initiation of this effect, is obtained. Its numerical value is in agreement with the obtained experimental data. It is shown experimentally that the discovered decapsulation effect is caused by the presence of gold nanorods connected to the liposomal shell of the capsules and does not arise in the absence of nanorods.
| Тип объекта: | Доклад на конференции или семинаре (Доклад) |
|---|---|
| Авторы на русском. ОБЯЗАТЕЛЬНО ДЛЯ АНГЛОЯЗЫЧНЫХ ПУБЛИКАЦИЙ!: | Вдовин В.А., Гуляев Ю.В., Черепенин В.А., Таранов И.В., Ярославов А.А., Ким В.П., Хомутов Г.Б. |
| Подразделения (можно выбрать несколько, удерживая Ctrl): | 164 лаб. устройств молекулярной и биологической электроники 201 лаб. математических методов радиофизики |
| URI: | http://cplire.ru:8080/id/eprint/3762 |
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